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A study in rats also investigated the influence of gestational nicotine on the offsprings sensitivity to natural and drug rewards [ Another study showed that sustained exposure to low doses of nicotine (3 mg/kg/day) during fetal development produced substantial changes in the developing corticostriatal dopamine system including both sex-dependent and sex-independent effects on the prefrontal dopamine systems [165]

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Hyland A, Li Q, Bauer JE, Giovino GA, Steger C, Cummings M

We see these countries clustered on the far left, where smoking rates for women are very low typically less than 5%